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Acute intermittent porphyria ..the safe and the unsafe drugs

Drugs considered safe in patients with porphyria

Drugs to avoid in patients with porphyria

Sedatives: propofol, etomidate, nitrous oxide

Sedatives: barbituates, diazepam, chlordiazepoxide

Analgesics: fentanyl, meperidine, morphine, droperidol, procaine

Analgesics: pentazocine, lidocaine

Others: promethazine, chlorpromazine,succinylcholine, pancuronium, neostigme, atropine

Anticonvulsants: phenytoin

Antibiotics: sulfonamides, chloramphenicol

 

Hypoglycemic agents: tolbutamide, clorpropamide

 

Others: ethanol, ergot derivatives, amphetamines, methyldopa, oral contraceptives

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