β-blockers are contraindicated to treat a hypertensive crisis from phenylephrine (such as an accidental overdose). β-blockers in this situation can reduce myocardial contractility and produce acute pulmonary edema in the face of high afterload.
Groudine SB, Hollinger I, Jones J, DeBouno BA. New York State guidelines on the topical use of phenylephrine in the operating room: the Phenylephrine Advisory Committee. Anesthesiology. 2000;92:
859-864.
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