Blood brain barrier...

Most capillary beds contain fenestrations between endothelial cells that are approximately 65 Ångstroms in diameter. In the brain, with the exception of the choroid plexus, pituitary,

and area postrema, tight junctions reduce this pore size to approximately 8 Ångstroms. As a result, large molecules and most ions (including pharmacologic agents with these characteristics) are prevented from entering the brain’s interstitium or from passing between the plasma and CSF.

Comments

The 100 essentials in icu and anesthesia

The most visual experience in anesthesia and critical care education The 100 essentials of anesthesia and critical care COMING VERY SOON stay tuned

Driving Pressure in ARDS: A new concept!

Driving Pressure and Survival in the Acute Respiratory Distress Syndrome Marcelo B.P. Amato, M.D., Maureen O. Meade, M.D., Arthur S. Slutsky, M.D., Laurent Brochard, M.D., Eduardo L.V. Costa, M.D., David A. Schoenfeld, Ph.D., Thomas E. Stewart, M.D., Matthias Briel, M.D., Daniel Talmor, M.D., M.P.H., Alain Mercat, M.D., Jean-Christophe M. Richard, M.D., Carlos R.R. Carvalho, M.D., and Roy G. Brower, M.D. N Engl J Med 2015; 372:747-755 February 19, 2015 DOI: 10.1056/NEJMsa1410639 BACKGROUND Mechanical-ventilation strategies that use lower end-inspiratory (plateau) airway pressures, lower tidal volumes (V T ), and higher positive end-expiratory pressures (PEEPs) can improve survival in patients with the acute respiratory distress syndrome (ARDS), but the relative importance of each of these components is uncertain. Because respiratory-system compliance (C RS ) is strongly related to the volume of aerated remaining functional lung during disease (termed functional lung size)...

Steroids equivalent doses

Steroid Glucocorticoid Potency Mineralocorticoid Potency Equivalent Dose Hydrocortisone 1 1 20 Prednisone 4 0.8 5 Prednisolone 4 0.8 5 Methylprednisolone 5 0.5 4 Triamcinolone 5 0 4 Dexamethasone 30-40 0 0.75

sedationstation

Search This Blog