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Reaction to protamine...the risk factors



Condition
Risk Increase
Prior reaction to protamine
189-fold
Allergy to true ( vertebrate ) fish
24.5-fold
Exposure to NPH insulin
8.2-fold
Allergy to any drug
3-fold
Prior exposure to protamine
No increase !



Adapted from Kimmel SE, Sekeres MA, Berlin JA, et al. Risk factors for clinically important adverse events after protamine administration following CPB. J Am Coll Card 1998;32:1916

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