Skip to main content

Lipase and amylase in Pancreatitis

Serum lipase is generally thought to be more sensitive and specific than amylase, but either enzyme may be used to diagnose acute pancreatitis (see diagnostic criteria).
In a retrospective study of 306 patients, Chase et al. reported the following sensitivities and specificities for amylase and lipase at > 3x the upper limit of normal.
Amylase and Lipase Sensitivities

Both enzymes typically begin to rise within the first 2-6 hrs and peak in 12-30 hrs.  Lipase, however, remains elevated for longer and may not return to baseline for 7-14 days compared with 2-4 days for amylase

Kiriyama S, Gabata T, et al., New Diagnostic Criteria of Acute Pancreatitis. J Hepatobiliary Pancreat Sci. 2010;17: 24-36.

Comments

Post a Comment

Popular posts from this blog

The 100 essentials in icu and anesthesia

The most visual experience in anesthesia and critical care education  The 100 essentials of anesthesia and critical care  COMING VERY SOON  stay tuned 
Post a Comment
Read more

Driving Pressure in ARDS: A new concept!

Driving Pressure and Survival in the Acute Respiratory Distress Syndrome Marcelo B.P. Amato, M.D., Maureen O. Meade, M.D., Arthur S. Slutsky, M.D., Laurent Brochard, M.D., Eduardo L.V. Costa, M.D., David A. Schoenfeld, Ph.D., Thomas E. Stewart, M.D., Matthias Briel, M.D., Daniel Talmor, M.D., M.P.H., Alain Mercat, M.D., Jean-Christophe M. Richard, M.D., Carlos R.R. Carvalho, M.D., and Roy G. Brower, M.D. N Engl J Med 2015; 372:747-755 February 19, 2015 DOI: 10.1056/NEJMsa1410639 BACKGROUND Mechanical-ventilation strategies that use lower end-inspiratory (plateau) airway pressures, lower tidal volumes (V T ), and higher positive end-expiratory pressures (PEEPs) can improve survival in patients with the acute respiratory distress syndrome (ARDS), but the relative importance of each of these components is uncertain. Because respiratory-system compliance (C RS ) is strongly related to the volume of aerated remaining functional lung during disease (termed functional lung size)...
6 comments
Read more