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Inhaled agents....rule of 2s


A simple mnemonic to remember the hepatic metabolism of inhaled anesthetics is the so-called "Rule of 2's." 
Halothane is roughly 20% metabolized,
 enflurane 2%, 
isoflurane 0.2%, 
desflurane 0.02%, 
sevoflurane roughly 4% (2% x 2). 
The hepatic metabolism of nitrous oxide is negligible. 
Of the inhaled anesthetics that are now available clinically, sevoflurane undergoes the most hepatic metabolism.

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