Anaphylaxis..the best route to save lives

Anesthesia practice is associated with polypharmacy ....polypharmacy is highly linked to anaphylaxis...all of us know that adrenalin is the drug of choice....but maybe still contraversial which route is the best......here is the answer..

The therapeutic algorithm for anaphylaxis should begin with epinephrine 0.3-0.5 mg IM, which can be repeated every 5-15 minutes.

The intramuscular route has been shown to have better absorption and more rapid peak plasma concentrations than the subcutaneous route and is therefore the route of choice.

If the patient is still in extremis, then a diluted solution of epinephrine 0.1mg should be given intravenously.
Extreme caution should be used when giving epinephrine intravenously as most adverse effects are from this route.

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In the pressure-volume loop below, cardiac work is best represented by: the area of the curve the slope of the line from points C to D the distance of the line from points C to D the slope of a line from points A to D .. .. ... .... ... .... .... .... In the pressure-volume loop below, cardiac work is best represented by: the area of the curve Cardiac work is the product of pressure and volume and is linearly related to myocardial oxygen consumption. Cardiac work is best represented by the area of the curve of a pressure-volume loop.

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