Bleeding continues to be the Achilles heel of systemic anticoagulation, whether the agent used is warfarin or any of the new anticoagulants entering the market. Predictive models for bleeding include the following:
- HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly, Drugs/alcohol)
- HEMORR2HAGES (hepatic or renal disease, ethanol abuse, malignancy, elderly, reduced platelet count or function, rebleeding, hypertension, anemia, genetic factors, excessive fall risk, stroke)
HAS-BLED beat two other scoring systems in a comparative analysis of trial data.
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