Maybe too much pain relief is bad?

This recent drug trial and editorial click here published in NEJM September 2010 show the outcome of too much analgesia when treating osteoarthritis of the knee. The study drug was Tanezumab, a monoclonal antibody that blocks nerve growth factor which then produces pain relief. Unfortunately the drug was too effective, which caused some patients to wear out their knees so badly they needed knee replacements. Consequently the FDA has put a halt on the studies with Tanezumab.

Comments

The 100 essentials in icu and anesthesia

The most visual experience in anesthesia and critical care education The 100 essentials of anesthesia and critical care COMING VERY SOON stay tuned

Driving Pressure in ARDS: A new concept!

Driving Pressure and Survival in the Acute Respiratory Distress Syndrome Marcelo B.P. Amato, M.D., Maureen O. Meade, M.D., Arthur S. Slutsky, M.D., Laurent Brochard, M.D., Eduardo L.V. Costa, M.D., David A. Schoenfeld, Ph.D., Thomas E. Stewart, M.D., Matthias Briel, M.D., Daniel Talmor, M.D., M.P.H., Alain Mercat, M.D., Jean-Christophe M. Richard, M.D., Carlos R.R. Carvalho, M.D., and Roy G. Brower, M.D. N Engl J Med 2015; 372:747-755 February 19, 2015 DOI: 10.1056/NEJMsa1410639 BACKGROUND Mechanical-ventilation strategies that use lower end-inspiratory (plateau) airway pressures, lower tidal volumes (V T ), and higher positive end-expiratory pressures (PEEPs) can improve survival in patients with the acute respiratory distress syndrome (ARDS), but the relative importance of each of these components is uncertain. Because respiratory-system compliance (C RS ) is strongly related to the volume of aerated remaining functional lung during disease (termed functional lung size)...

Steroids equivalent doses

Steroid Glucocorticoid Potency Mineralocorticoid Potency Equivalent Dose Hydrocortisone 1 1 20 Prednisone 4 0.8 5 Prednisolone 4 0.8 5 Methylprednisolone 5 0.5 4 Triamcinolone 5 0 4 Dexamethasone 30-40 0 0.75

sedationstation

Search This Blog