Recent evidence suggests equivalent, and possibly superior, outcomes when neonatal resuscitation is initiated with room air.
Evidence of harm from oxygen therapy includes oxidative damage, as well as a possible association with increased rates of childhood malignancy.
In 2010, the American Heart Association and the European Resuscitation Council recommend initial resuscitation with air rather than oxygen.
The need for supplemental oxygen should be guided by a pulse oximeter attached to the right upper extremity (preductal). Blended air and oxygen should only be used if there is no improvement in oxygenation.
Dawson et al. used a prospective cohort of 468 term and preterm infants to create reference ranges (3rd to 97th percentiles) for oxygen saturation measurements in the first 10 minutes of life. It is important to note that in term infants, it takes approximately 8 minutes to reach an oxygen saturation 90%, and slightly longer in preterm infants.
The table below shows targeted oxygen saturation values, by time of delivery, as recommended by the updated American Heart Association.
| Time after birth | Targeted preductal SpO2 after birth |
| 1 min | 60%-65% |
| 2 min | 65%-70% |
| 3 min | 70%-75% |
| 4 min | 75%-80% |
| 5 min | 80%-85% |
| 10 min | 85%-90% |
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