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Naloxone...in Nebulizer



Nebulized naloxone
The beauty of naloxone is that it can be administered through a variety of routes which includes IV, IM, and intranasal. Reported in 2003 in the Journal of EM, the nebulized route is also effective.

Advantages:
  • Nebulized naloxone does not require an IV, which is often difficult to establish in IV drug users.
  • Instead of administering multiple doses of naloxone for long-acting opiates, nebulized naloxone can provide a steady, low maintenance dose similar to an IV drip but without needing an IV.
  • Nebulized naloxone is a self-titrating medication because when the patient awakens, s/he often will pull off the mask.

A good starting regimen is 1-2 mg naloxone in a total volume of 3-5 mL. You may need to add normal saline to reach the target volume. I recently used 1 mg naloxone in 3 mL with great success. The patient was able to give a brief history and remained non-agitated. For longer-term naloxone treatment, you will need to refill the nebulizer canister intermittently or request a large-volume nebulizer canister.

Note: If you need to reverse opiates more quickly, you might consider giving an intranasal dose of naloxone first, followed by a maintenance dose using the nebulizer.
Thanks to Dr. Ethan Cowane (Jacobi Medical Center) for this tip!

Reference

Mycyk MB, Szyszko AL, Aks SE. Nebulized naloxone gently and effectively reverses methadone intoxication. J Emerg Med. 2003 Feb;24(2):185-7.
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